|Other Names||Protein SMG5, EST1-like protein B, LPTS-RP1, LPTS-interacting protein, SMG-5 homolog, hSMG-5, SMG5, EST1B, KIAA1089|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.|
|Cellular Location||Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies|
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Provided below are standard protocols that you may find useful for product applications.
SMG5 is involved in nonsense-mediated mRNA decay (Ohnishiet al., 2003 [PubMed 14636577]).
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Glavan, F., et al. EMBO J. 25(21):5117-5125(2006)Lee, H., et al. Mol. Cell. Biol. 26(14):5259-5269(2006)Azzalin, C.M., et al. Curr. Biol. 16(4):433-439(2006)Unterholzner, L., et al. Mol. Cell 16(4):587-596(2004)
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