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DNER Antibody(C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q8NFT8
Clone Names 110717047
Additional Information
Other Names Delta and Notch-like epidermal growth factor-related receptor, DNER, BET
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms BET
Function Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity).
Tissue Location Expressed in brain, spinal cord and adrenal gland. EMBL; AF442487; AAM21557.1; -; mRNA EMBL; AY358891; AAQ89250.1; -; mRNA EMBL; AC007559; AAY14939.1; -; Genomic_DNA EMBL; AC007748; AAY24263.1; -; Genomic_DNA EMBL; AC008273; AAF19247.2; -; Genomic_DNA EMBL; AC093384; AAY14680.1; -; Genomic_DNA EMBL; CH471063; EAW70893.1; -; Genomic_DNA EMBL; BC024766; AAH24766.2; -; mRNA EMBL; BC035009; AAH35009.1; -; mRNA EMBL; AL137311; CAB70690.1; -; mRNA CCDS; CCDS33390.1; - PIR; T46247; T46247 RefSeq; NP_620711.3; NM_139072.3 SMR; Q8NFT8; - BioGRID; 124973; 2 DIP; DIP-46249N; - IntAct; Q8NFT8; 4 STRING; 9606.ENSP00000345229; - GlyGen; Q8NFT8; 3 sites iPTMnet; Q8NFT8; - PhosphoSitePlus; Q8NFT8; - BioMuta; DNER; - DMDM; 74730301; - EPD; Q8NFT8; - jPOST; Q8NFT8; - MassIVE; Q8NFT8; - MaxQB; Q8NFT8; - PaxDb; Q8NFT8; - PeptideAtlas; Q8NFT8; - PRIDE; Q8NFT8; - ProteomicsDB; 73354; - Antibodypedia; 2715; 220 antibodies Ensembl; ENST00000341772; ENSP00000345229; ENSG00000187957 GeneID; 92737; - KEGG; hsa:92737; - UCSC; uc002vpv.4; human CTD; 92737; - DisGeNET; 92737; - EuPathDB; HostDB:ENSG00000187957.7; - GeneCards; DNER; - HGNC; HGNC:24456; DNER HPA; ENSG00000187957; Group enriched (adrenal gland, brain, salivary gland) MIM; 607299; gene neXtProt; NX_Q8NFT8; - OpenTargets; ENSG00000187957; - PharmGKB; PA162383959; - eggNOG; KOG1217; Eukaryota GeneTree; ENSGT00940000158872; - HOGENOM; CLU_019513_0_0_1; - InParanoid; Q8NFT8; - OMA; CLDQSNG; - OrthoDB; 7525at2759; - PhylomeDB; Q8NFT8; - TreeFam; TF351322; - PathwayCommons; Q8NFT8; - Reactome; R-HSA-2122948; Activated NOTCH1 Transmits Signal to the Nucleus SignaLink; Q8NFT8; - SIGNOR; Q8NFT8; - BioGRID-ORCS; 92737; 4 hits in 874 CRISPR screens ChiTaRS; DNER; human GeneWiki; DNER; - GenomeRNAi; 92737; - Pharos; Q8NFT8; Tbio PRO; PR:Q8NFT8; - Proteomes; UP000005640; Chromosome 2 RNAct; Q8NFT8; protein Bgee; ENSG00000187957; Expressed in cerebellar vermis and 175 other tissues Genevisible; Q8NFT8; HS GO; GO:0030425; C:dendrite; IDA:UniProtKB GO; GO:0005769; C:early endosome; IDA:UniProtKB GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0043025; C:neuronal cell body; IEA:Ensembl GO; GO:0005886; C:plasma membrane; IDA:UniProtKB GO; GO:0005509; F:calcium ion binding; NAS:UniProtKB GO; GO:0030276; F:clathrin binding; TAS:UniProtKB GO; GO:0005112; F:Notch binding; IBA:GO_Central GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:UniProtKB GO; GO:0007417; P:central nervous system development; IEP:UniProtKB GO; GO:0006897; P:endocytosis; NAS:UniProtKB GO; GO:0010001; P:glial cell differentiation; IEA:Ensembl GO; GO:0001764; P:neuron migration; NAS:UniProtKB GO; GO:0007220; P:Notch receptor processing; IEA:Ensembl GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW GO; GO:0048741; P:skeletal muscle fiber development; IEA:Ensembl GO; GO:0007416; P:synapse assembly; NAS:UniProtKB InterPro; IPR001881; EGF-like_Ca-bd_dom InterPro; IPR013032; EGF-like_CS InterPro; IPR000742; EGF-like_dom InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site InterPro; IPR018097; EGF_Ca-bd_CS InterPro; IPR009030; Growth_fac_rcpt_cys_sf Pfam; PF00008; EGF; 6 Pfam; PF12661; hEGF; 1 SMART; SM00181; EGF; 10 SMART; SM00179; EGF_CA; 7 SUPFAM; SSF57184; SSF57184; 2 PROSITE; PS00010; ASX_HYDROXYL; 2 PROSITE; PS00022; EGF_1; 10 PROSITE; PS01186; EGF_2; 7 PROSITE; PS50026; EGF_3; 10 PROSITE; PS01187; EGF_CA; 2 1: Evidence at protein level; Activator; Calcium; Cell membrane; Disulfide bond; EGF-like domain; Glycoprotein; Membrane; Notch signaling pathway; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1..34 /evidence="ECO:0000255" CHAIN 35..737 /note="Delta and Notch-like epidermal growth factor-related receptor" /id="PRO_0000253557" TOPO_DOM 35..640 /note="Extracellular" /evidence="ECO:0000255" TRANSMEM 641..661 /note="Helical" /evidence="ECO:0000255" TOPO_DOM 662..737 /note="Cytoplasmic" /evidence="ECO:0000255" DOMAIN 44..92 /note="EGF-like 1" /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DOMAIN 94..133 /note="EGF-like 2" /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DOMAIN 309..348 /note="EGF-like 3" /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DOMAIN 349..390 /note="EGF-like 4" /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DOMAIN 392..428 /note="EGF-like 5" /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DOMAIN 430..466 /note="EGF-like 6" /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DOMAIN 468..503 /note="EGF-like 7" /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DOMAIN 505..541 /note="EGF-like 8; calcium-binding" /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DOMAIN 543..579 /note="EGF-like 9" /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DOMAIN 546..568 /note="Follistatin-like" DOMAIN 581..617 /note="EGF-like 10; calcium-binding" /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" REGION 44..133 /note="Interaction with NOTCH1" /evidence="ECO:0000250" REGION 677..680 /note="Interaction with AP1G1 and somatodendritic targeting" /evidence="ECO:0000250" MOD_RES 685 /note="Phosphoserine" /evidence="ECO:0000250|UniProtKB:Q8JZM4" MOD_RES 711 /note="Phosphotyrosine" /evidence="ECO:0000250|UniProtKB:Q8JZM4" MOD_RES 721 /note="Phosphotyrosine" /evidence="ECO:0000250|UniProtKB:Q8JZM4" MOD_RES 722 /note="Phosphoserine" /evidence="ECO:0000250|UniProtKB:Q8JZM4" CARBOHYD 223 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000269|PubMed:16740002" CARBOHYD 564 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" DISULFID 48..59 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 53..80 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 82..91 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 98..108 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 103..121 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 123..132 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 319..336 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 338..347 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 353..364 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 358..378 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 380..389 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 396..407 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 401..416 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 418..427 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 434..445 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 439..454 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 456..465 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 472..482 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 477..491 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 493..502 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 509..520 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 514..529 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 531..540 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 547..558 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 552..567 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 569..578 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 585..596 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 590..605 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" DISULFID 607..616 /evidence="ECO:0000255|PROSITE-ProRule:PRU00076" VARIANT 433 /note="P -> L (in dbSNP:rs17853365)" /evidence="ECO:0000269|PubMed:15489334" /id="VAR_028380" SEQUENCE 737 AA; 78475 MW; 25A8A8A3044308BE CRC64; MQPRRAQAPG AQLLPALALL LLLLGAGPRG SSLANPVPAA PLSAPGPCAA QPCRNGGVCT SRPEPDPQHP APAGEPGYSC TCPAGISGAN CQLVADPCAS NPCHHGNCSS SSSSSSDGYL CICNEGYEGP NCEQALPSLP ATGWTESMAP RQLQPVPATQ EPDKILPRSQ ATVTLPTWQP KTGQKVVEMK WDQVEVIPDI ACGNASSNSS AGGRLVSFEV PQNTSVKIRQ DATASLILLW KVTATGFQQC SLIDGRSVTP LQASGGLVLL EEMLALGNNH FIGFVNDSVT KSIVALRLTL VVKVSTCVPG ESHANDLECS GKGKCTTKPS EATFSCTCEE QYVGTFCEEY DACQRKPCQN NASCIDANEK QDGSNFTCVC LPGYTGELCQ SKIDYCILDP CRNGATCISS LSGFTCQCPE GYFGSACEEK VDPCASSPCQ NNGTCYVDGV HFTCNCSPGF TGPTCAQLID FCALSPCAHG TCRSVGTSYK CLCDPGYHGL YCEEEYNECL SAPCLNAATC RDLVNGYECV CLAEYKGTHC ELYKDPCANV SCLNGATCDS DGLNGTCICA PGFTGEECDI DINECDSNPC HHGGSCLDQP NGYNCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF ILMLIILIVG ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA RFGKKSRPAM YDVSPIAYED YSPDDKPLVT LIKTKDL
Research Areas
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Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity).


Kurisu, J., et al. J. Neurochem. 113(6):1598-1610(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Park, J.R., et al. Cell Prolif. 43(1):19-28(2010)Ramachandran, P., et al. J. Proteome Res. 5(6):1493-1503(2006)Hillier, L.W., et al. Nature 434(7034):724-731(2005)

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$ 277.78
Cat# BP19467b
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