RCL1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y2P8 |
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Clone Names | 50908346 |
Gene ID | 10171 |
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Other Names | RNA 3'-terminal phosphate cyclase-like protein, RCL1, RNAC, RPC2, RPCL1, RTC2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1949a was selected from the N-term region of human RCL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RCL1 (HGNC:17687) |
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Synonyms | RNAC, RPC2, RPCL1, RTC2 |
Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome (PubMed:34516797). Does not have cyclase activity (By similarity). |
Cellular Location | Nucleus, nucleolus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
RCL1, which does not have cyclase activity, plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
References
Billy, E., et al., EMBO J. 19(9):2115-2126 (2000). Genschik P., et al., EMBO J. 16(10):2955-67 (1997).
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