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CLIC6 Antibody(C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96NY7 |
|---|---|
| Clone Names | 100405271 |
| Gene ID | 54102 |
|---|---|
| Other Names | Chloride intracellular channel protein 6, Parchorin, CLIC6, CLIC1L |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLIC6 {ECO:0000303|PubMed:37838179, ECO:0000312|HGNC:HGNC:2065} |
|---|---|
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (PubMed:37838179). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). |
| Cellular Location | Cytoplasm. Cell membrane; Single-pass membrane protein Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity) |
| Tissue Location | Expressed in brain, placenta, pancreas, liver, lung, heart, kidney, liver, spleen, soleus muscle, and brown fat |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the chloride intracellularchannel family of proteins. The gene is part of a large triplicatedregion found on chromosomes 1, 6, and 21. An alternatively splicedtranscript variant has been described, but its biological validityhas not been determined.
References
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :Friedli, M., et al. Gene 320, 31-40 (2003) :Strippoli, P., et al. Mamm. Genome 13(8):456-462(2002)Scanlan, M.J., et al. Cancer Immun. 1, 4 (2001) :
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