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Neurogenin1 (NeuroG1) Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q92886
Other Accession NP_006152
Clone Names 2120411
Additional Information
Other Names Neurogenin-1, NGN-1, Class A basic helix-loop-helix protein 6, bHLHa6, Neurogenic basic-helix-loop-helix protein, Neurogenic differentiation factor 3, NeuroD3, NEUROG1, BHLHA6, NEUROD3, NGN, NGN1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2022a was selected from the N-term region of human NeuroG1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NEUROG1
Synonyms BHLHA6, NEUROD3, NGN, NGN1
Function Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
Cellular Location Nucleus.
Tissue Location Expression restricted to the embryonic nervous system EMBL; U63842; AAB37575.1; -; Genomic_DNA EMBL; BT019366; AAV38173.1; -; mRNA EMBL; CH471062; EAW62214.1; -; Genomic_DNA EMBL; BC008687; AAH08687.1; -; mRNA EMBL; BC028226; AAH28226.1; -; mRNA CCDS; CCDS4187.1; - RefSeq; NP_006152.2; NM_006161.2 SMR; Q92886; - BioGRID; 110835; 8 IntAct; Q92886; 2 STRING; 9606.ENSP00000317580; - iPTMnet; Q92886; - PhosphoSitePlus; Q92886; - BioMuta; NEUROG1; - DMDM; 37538313; - PaxDb; Q92886; - PeptideAtlas; Q92886; - PRIDE; Q92886; - ProteomicsDB; 75570; - Antibodypedia; 26408; 572 antibodies DNASU; 4762; - Ensembl; ENST00000314744; ENSP00000317580; ENSG00000181965 GeneID; 4762; - KEGG; hsa:4762; - UCSC; uc003lax.3; human CTD; 4762; - DisGeNET; 4762; - EuPathDB; HostDB:ENSG00000181965.5; - GeneCards; NEUROG1; - HGNC; HGNC:7764; NEUROG1 HPA; ENSG00000181965; Group enriched (brain, retina, testis) MIM; 601726; gene neXtProt; NX_Q92886; - OpenTargets; ENSG00000181965; - PharmGKB; PA31569; - eggNOG; KOG3898; Eukaryota GeneTree; ENSGT00940000162170; - HOGENOM; CLU_097959_0_0_1; - InParanoid; Q92886; - KO; K09081; - OMA; QCAPCLP; - OrthoDB; 1524429at2759; - PhylomeDB; Q92886; - TreeFam; TF315153; - PathwayCommons; Q92886; - SIGNOR; Q92886; - BioGRID-ORCS; 4762; 4 hits in 887 CRISPR screens GeneWiki; NEUROG1; - GenomeRNAi; 4762; - Pharos; Q92886; Tbio PRO; PR:Q92886; - Proteomes; UP000005640; Chromosome 5 RNAct; Q92886; protein Bgee; ENSG00000181965; Expressed in subventricular zone (outer) (primate) and 19 other tissues ExpressionAtlas; Q92886; baseline and differential Genevisible; Q92886; HS GO; GO:0000790; C:nuclear chromatin; ISA:NTNU_SB GO; GO:0043204; C:perikaryon; IEA:Ensembl GO; GO:0003682; F:chromatin binding; ISS:UniProtKB GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB GO; GO:0070888; F:E-box binding; IDA:CAFA GO; GO:0042803; F:protein homodimerization activity; IDA:CAFA GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:CAFA GO; GO:0031223; P:auditory behavior; IGI:CAFA GO; GO:0045165; P:cell fate commitment; IEA:Ensembl GO; GO:0090102; P:cochlea development; IGI:CAFA GO; GO:0090103; P:cochlea morphogenesis; IGI:CAFA GO; GO:0097094; P:craniofacial suture morphogenesis; IGI:CAFA GO; GO:0048806; P:genitalia development; IGI:CAFA GO; GO:0035112; P:genitalia morphogenesis; IGI:CAFA GO; GO:1905748; P:hard palate morphogenesis; IGI:CAFA GO; GO:0048839; P:inner ear development; IGI:CAFA GO; GO:0042472; P:inner ear morphogenesis; IGI:CAFA GO; GO:0098583; P:learned vocalization behavior; IGI:CAFA GO; GO:0071626; P:mastication; IGI:CAFA GO; GO:1901078; P:negative regulation of relaxation of muscle; IGI:CAFA GO; GO:1905747; P:negative regulation of saliva secretion; IGI:CAFA GO; GO:0007399; P:nervous system development; TAS:ProtInc GO; GO:0050885; P:neuromuscular process controlling balance; IGI:CAFA GO; GO:0030182; P:neuron differentiation; IEA:Ensembl GO; GO:0030432; P:peristalsis; IGI:CAFA GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:UniProtKB GO; GO:0031536; P:positive regulation of exit from mitosis; IEA:Ensembl GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB GO; GO:0048634; P:regulation of muscle organ development; IGI:CAFA GO; GO:0006357; P:regulation of transcription by RNA polymerase II; TAS:ProtInc GO; GO:0007356; P:thorax and anterior abdomen determination; IGI:CAFA GO; GO:0021559; P:trigeminal nerve development; IGI:CAFA GO; GO:0021650; P:vestibulocochlear nerve formation; IGI:CAFA CDD; cd00083; HLH; 1 DisProt; DP00672; - Gene3D; 4.10.280.10; -; 1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf InterPro; IPR032653; Ngn1 PANTHER; PTHR19290:SF130; PTHR19290:SF130; 1 Pfam; PF00010; HLH; 1 SMART; SM00353; HLH; 1 SUPFAM; SSF47459; SSF47459; 1 PROSITE; PS50888; BHLH; 1 1: Evidence at protein level; Activator; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1..237 /note="Neurogenin-1" /id="PRO_0000127396" DOMAIN 92..144 /note="bHLH" /evidence="ECO:0000255|PROSITE-ProRule:PRU00981" CONFLICT 51 /note="G -> S (in Ref. 1; AAB37575)" /evidence="ECO:0000305" SEQUENCE 237 AA; 25718 MW; E3702A0B3408D567 CRC64; MPARLETCIS DLDCASSSGS DLSGFLTDEE DCARLQQAAS ASGPPAPARR GAPNISRASE VPGAQDDEQE RRRRRGRTRV RSEALLHSLR RSRRVKANDR ERNRMHNLNA ALDALRSVLP SFPDDTKLTK IETLRFAYNY IWALAETLRL ADQGLPGGGA RERLLPPQCV PCLPGPPSPA SDAESWGSGA AAASPLSDPS SPAASEDFTY RPGDPVFSFP SLPKDLLHTT PCFIPYH
Research Areas
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Background

Basic helix-loop-helix (bHLH) proteins are transcription factors involved in determining cell type during development. NeuroG1 is a bHLH protein with dual cell-fate specification roles. It functions during neurogenesis, and it has also been shown to inhibit the differentiation of neural stem cells into astrocytes. NeuroG1 promotes neurogenesis by functioning as a transcriptional activator, yet it inhibits astrocyte differentiation by compartmentalizing the CREB-binding protein transcription complex away from astrocyte differentiation genes and by inhibiting STAT transcription factors essential for gliogenesis.

References

Tamimi, R.M., et al., Genomics 40(2):355-357 (1997).McCormick, M.B., et al., Mol. Cell. Biol. 16(10):5792-5800 (1996).

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$ 277.78
Cat# BP2022a
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