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PTGES2 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H7Z7 |
|---|
| Gene ID | 80142 |
|---|---|
| Other Names | Prostaglandin E synthase 2, Membrane-associated prostaglandin E synthase-2, mPGE synthase-2, Microsomal prostaglandin E synthase 2, mPGES-2, Prostaglandin-H(2) E-isomerase, Prostaglandin E synthase 2 truncated form, PTGES2, C9orf15, PGES2 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 133-146 of HUMAN PTGES2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PTGES2 |
|---|---|
| Synonyms | C9orf15, PGES2 |
| Function | Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:18198127, PubMed:17585783). The biological function and the GSH- dependent property of PTGES2 is still under debate (PubMed:18198127, PubMed:17585783). In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy- 5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:17585783) (By similarity). |
| Cellular Location | Golgi apparatus membrane; Single-pass membrane protein |
| Tissue Location | Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Humphray S.J.,et al.Nature 429:369-374(2004).
Tanikawa N.,et al.Biochem. Biophys. Res. Commun. 291:884-889(2002).
Watanabe K.,et al.Biochem. Biophys. Res. Commun. 306:577-581(2003).
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