|Other Names||E3 ubiquitin-protein ligase TRIM69, 632-, RFP-like domain-containing protein trimless, RING finger protein 36, Tripartite motif-containing protein 69, TRIM69, RNF36|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP2525c was selected from the Center region of human TRIM69. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus speckle|
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Provided below are standard protocols that you may find useful for product applications.
TRIM69 is a member of the RING-B-box-coiled-coil (RBCC) family with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of TRIM69 is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis.
Shyu,H.W., Exp. Cell Res. 287 (2), 301-313 (2003)Shyu,H.W., Mech. Dev. 108 (1-2), 213-216 (2001)
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