TNFRSF13B Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O14836 |
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Clone Names | 90713213 |
Gene ID | 23495 |
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Other Names | Tumor necrosis factor receptor superfamily member 13B, Transmembrane activator and CAML interactor, CD267, TNFRSF13B, TACI |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8557a was selected from the N-term region of human TNFRSF13B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TNFRSF13B |
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Synonyms | TACI |
Function | Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin- dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. |
Cellular Location | Membrane; Single-pass type III membrane protein. |
Tissue Location | Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
TNFRSF13B is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1,and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand.
References
Waldrep,M.L., et.al., BMC Med. Genet. 10, 100 (2009)Lee,J.J., Rauter,I., et.al., Blood 114 (11), 2254-2262 (2009)
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