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Adipophilin, human, recombinant protein
Adipose differentiation-related protein, ADRP, ADFP, MGC10598.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q99541 |
|---|---|
| Calculated MW | 49.0 kDa |
| Gene ID | 123 |
|---|---|
| Gene Symbol | PLIN2 |
| Other Names | Adipose differentiation-related protein, ADRP, ADFP, MGC10598, Perilipin-2 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Target/Specificity | Adipophilin |
| Application Notes | Add de-ionized H₂O to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized from 0.5 mg/ml solution containing 20mM Tris pH 7.5, and 20 mM NaCl, |
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Provided below are standard protocols that you may find useful for product applications.
Background
Adipophilin is a 49 kDa protein that belongs to the PAT family (perilipin, adipophilin, TIP47, S3-12 and OXPAT), which comprises proteins involved in the coating of lipid droplets. ADFP is expressed in lipid droplets of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes. ADFP expression has a role in clear cell renal carcinoma differentiation. Most recently, it has been discovered that patients with kidney cancers had high levels of ADFP in their urine, suggesting that ADFP could be an excellent marker for kidney cancer.
References
Heid H.W.,et al.Biochem. J. 320:1025-1030(1996).
Tangkeangsirisin W.,et al.Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Bienvenut W.V.,et al.Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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