News & Announcements
Abgent offers a portfolio of antibodies for the detection of Pyruvate dehydrogenase kinase isozyme 4 (PDK4) in western blotting, immunohistochemistry, and immunofluorescence.
Apr 13, 2015
Bone morphogenetic proteins (BMPs) belong to the large transforming growth factor-beta (TGF-beta) superfamily of multifunctional cytokines. Signaling of the BMPs requires the binding of the BMP to the BMP cell surface receptors BMPR-IA, BMPR-IB, and BMPR-II.
Apr 07, 2015
Glutaminase is the major enzyme yielding glutamate from glutamine. This enzyme catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Significance also arises from implication in behavior disturbances in which glutamate acts as a neurotransmitter.
Apr 02, 2015
LGR5, also known as GPR49, is a member of the Wnt signaling pathway expressed across a diverse range of tissues, and particularly as a biomarker of adult stem cells in certain tissues.
Mar 24, 2015
C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous…
Mar 16, 2015
Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells.
Mar 09, 2015
Check out Abgent's Oncogene Expression Reference Guide. This wall chart is an informative summary of key immuno-detectable oncogenes, organized by cellular location, expression levels, binding partners, pathway, disease, and more.
Mar 03, 2015
Glycogen synthase kinase 3 (GSK3) regulates glycogen synthesis in response to insulin. It is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase...
Mar 02, 2015
Abgent's anti-SHP2-Ab (Cat# AP8471e) has recently been used to detect the immunochemistry expression pattern in stage I-III colorectal carcinoma (CRC). SHP2 expression in CRC correlated to a good prognosis, indicating SHP2 tends to be a tumor suppressor in CRC.
Feb 23, 2015
ALK kinase is involved in the MAPK-pathway which contributes to cell proliferation induction and cancers such as inflammatory myofibroblastic tumors (IMTs), anaplastic large-cell lymphoma (ALCL), and adenocarcinoma. One of Abgent’s ALK antibodies was cited recently in Toxicol. Sci. 2015 Jan;143(1):116-25.
Feb 16, 2015