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> home > Products > Primary Antibodies > Antibody Collections > KD-Validated Antibodies > KD-Validated Anti-Helicase like transcription factor Rabbit Monoclonal Antibody
KD-Validated Anti-Helicase like transcription factor Rabbit Monoclonal Antibody
Rabbit monoclonal antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, ICC |
|---|---|
| Primary Accession | Q14527 |
| Reactivity | Human |
| Clonality | Monoclonal |
| Isotype | Rabbit IgG |
| Clone Names | 23GB 2485 |
| Calculated MW | Predicted, 114 kDa , observed, 120 kDa |
| Gene Name | HLTF |
| Aliases | HLTF; Helicase Like Transcription Factor; HIP116A; RNF80; SMARCA3; SNF2L3; HLTF1; SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 3; SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 3; RING-Type E3 Ubiquitin Transferase HLTF; Sucrose Nonfermenting Protein 2-Like 3; Helicase-Like Transcription Factor; RING Finger Protein 80; HIP116; ZBU1; DNA-Binding Protein/Plasminogen Activator Inhibitor-1 Regulator; DNA-Binding Protein/Plasminogen Activator Inhibitor 1 Regulator; Sucrose Nonfermenting-Like 3; SNF2-Like 3; EC 2.3.2.27; EC 3.6.4.-; EC 3.6.1 |
| Immunogen | A synthesized peptide derived from human HLTF |
| Gene ID | 6596 |
|---|---|
| Other Names | Helicase-like transcription factor, 2.3.2.27, 3.6.4.-, DNA-binding protein/plasminogen activator inhibitor 1 regulator, HIP116, RING finger protein 80, RING-type E3 ubiquitin transferase HLTF, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3, Sucrose nonfermenting protein 2-like 3, HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1 |
| Name | HLTF |
|---|---|
| Synonyms | HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1 |
| Function | Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. |
| Cellular Location | Cytoplasm. Nucleus. Nucleus, nucleolus Nucleus, nucleoplasm. Note=Nuclear localization is stimulated by progesterone. |
| Tissue Location | Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. |
Research Areas
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$ 149.00
$ 499.00
Cat# AGI1239
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