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CD27 Antibody (clone LG.3A10)
Hamster Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E, IP, FC |
|---|---|
| Primary Accession | P26842 |
| Other Accession | 939 |
| Reactivity | Human, Mouse |
| Host | Hamster |
| Clonality | Monoclonal |
| Isotype | IgG |
| Clone Names | LG.3A10 |
| Calculated MW | 29137 Da |
| Dilution | IHC-P (15 µg/ml), |
| Gene ID | 939 |
|---|---|
| Other Names | CD27, CD27 antigen, CD27 molecule, S152, T14, T-cell activation antigen CD27, CD27L receptor, T cell activation antigen S152, TNFRSF7, Tp55 |
| Target/Specificity | Cross-reacts with human CD27. |
| Reconstitution & Storage | PBS containing 0.09% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Precautions | CD27 Antibody (clone LG.3A10) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CD27 (HGNC:11922) |
|---|---|
| Function | Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells (PubMed:28011863). The CD70-CD27 signaling pathway mediates antigen- specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed:28011863). Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory (PubMed:38354704). In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis (By similarity). Negatively regulates the function of Th2 lymphocytes in the adipose tissue (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Found in most T-lymphocytes. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
References
Camerini D.,et al.J. Immunol. 147:3165-3169(1991).
Loenen W.A.,et al.J. Immunol. 149:3937-3943(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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