contactin 1 (aa585-870) Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC, E |
---|---|
Primary Accession | Q12860 |
Other Accession | NP_001834.2, NP_778203.1, 1272, 12805 (mouse), 117258 (rat) |
Reactivity | Human, Mouse, Rat |
Predicted | Pig, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 113320 Da |
Gene ID | 1272 |
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Other Names | Contactin-1, Glycoprotein gp135, Neural cell surface protein F3, CNTN1 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | contactin 1 (aa585-870) Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CNTN1 |
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Function | Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity). |
Cellular Location | [Isoform 1]: Cell membrane; Lipid-anchor, GPI- anchor; Extracellular side |
Tissue Location | Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle. |

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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize isoform 1 (NP_001834.2) and isoform 2 (NP_778203.1).
References
A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. Lamprianou S, Chatzopoulou E, Thomas JL, Bouyain S, Harroch S. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17498-503. PMID: 21969550

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